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Friday, July 24, 2020 | History

5 edition of Statistical issues in drug development found in the catalog.

Statistical issues in drug development

Stephen Senn

Statistical issues in drug development

by Stephen Senn

  • 343 Want to read
  • 14 Currently reading

Published by John Wiley & Sons in Chichester, England, Hoboken, NJ .
Written in English

    Subjects:
  • Drug development -- Statistical methods.,
  • Clinical Trials as Topic.,
  • Drug Design.,
  • Statistics as Topic -- methods.

  • Edition Notes

    Includes bibliographical references and index.

    StatementStephen Senn.
    SeriesStatistics in practice
    Classifications
    LC ClassificationsRM301.25 .S46 2007
    The Physical Object
    Paginationxix, 498 p. :
    Number of Pages498
    ID Numbers
    Open LibraryOL21577129M
    ISBN 100470018771
    ISBN 109780470018774
    LC Control Number2007045553

    Statistical issues in drug development [electronic resource] / Stephen Senn. Main author: Senn, Stephen. Corporate Author: Ebook Central Academic Complete., ProQuest (Firm) Format: eBook Edition: 2nd ed. Online access: Connect to electronic book via Ebook Central.   Statistical Issues in Drug Development presents an essential and thought provoking guide to the statistical issues and controversies involved in drug development. This highly readable second edition has been updated to include:* Comprehensive coverage of the design and interpretation of clinical trials.* Expanded sections on missing data Author: Senn.

    The reduced model, however, includes the centers as a factor. Clinical trials in drug development: Some statistical issues 49 (2) If the interaction is significant at the level of significance do an exploratory analysis to see if any covariate (in addition to those included in the model) can explain the by: 6. Statistical Issues in Drug Development presents an essential and thought provoking guide to the statistical issues and controversies involved in drug development. p. Series: Statistics in Practice. PREVIEW. Stephen Senn. Department of Statistics. University of Glasgow (UK). PublisherPublication date (print): ; ISBN (print):

    The drug development process is described from the viewpoint of statistical applications. The authors describe studies, data, methods, and results that finally lead to a new drug. The focus is on illustrating the practical problems and the statistical approaches to tackle them. David Michelson, vice president of clinical neuroscience and ophthalmology at Merck Research Laboratories, opened the workshop by underscoring drug discovery challenges for nervous system disorders. The years- to decades-long process can be complex, and there is nearly always a moment of uncertainty that a drug will succeed to the next phase of development.


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Statistical issues in drug development by Stephen Senn Download PDF EPUB FB2

Statistical Issues in Drug Development presents an essential and thought provoking guide to the statistical issues and controversies involved in drug development. This highly readable second edition has been updated to include: Comprehensive coverage of the design and interpretation of clinical by:   His books, Cross-over Trials in Clinical Research (, 2 nd edition ) and Statistical Issues in Drug Development () are published by Wiley and his latest book, Dicing with Death () by Cambridge University Press.

Inhe was the Statistical issues in drug development book recipient of the George C Challis award for biostatistics of the University of Florida. Statistical Issues in Drug Development, 2nd Edition | Wiley. Drug development is the process of finding and producing therapeutically useful pharmaceuticals, turning them into safe and effective medicine, and producing reliable information regarding the appropriate dosage and dosing intervals.

With regulatory authorities demanding increasingly higher standards in such developments, statistics has become an intrinsic and critical element in the design and conduct of drug development. Statistical Issues in Drug Development. This book for non-statisticians explains the statistical issues in drug development to help them plan, analyze and interpret clinical trials.

It also examines the commercial pressures, regulatory standards and high scrutiny that accompany this field.4/5(5). Statistical Issues in Drug Research and Development (Statistics: A Series of Textbooks and Monographs): Medicine & Health Science Books @ mat: Hardcover.

Statistical Issues in Drug Development presents an essential and thought provoking guide to the statistical issues and controversies involved in drug development.

This highly readable second edition has been updated to include: Comprehensive coverage of the design and interpretation of clinical trials.4/5(5). he has been Professor of Statistics at Glasgow University. His books, Cross-over Trials in Clinical Research (, 2 nd edition ) and Statistical Issues in Drug Development () are published by Wiley and his latest book, Dicing with Death () by Cambridge University Press.

This book is a compilation of topics addressed by the ASA Biopharmaceutical Section work groups, including the etiology and evolution of the work groups, the work group guidelines and structure, and the statistical issues associated with clinical trials in clinical drug development programs. The second edition of Statistical Issues in Drug Development updates a book originally published in and it maintains much of the same organization.

Senn has provided word counts for each chapter in the first and second edition. The average chapter has increased by about 2, words, with most of the increasesAuthor: Steve Simon. Statistical Issues in Drug Development presents an essential and thought provoking guide to the statistical issues and controversies involved in drug development.

This highly readable second edition has been updated to include: Comprehensive coverage of the design and interpretation of clinical trials. Statistical Issues in Drug Development (Statistics in Practice) Stephen Senn Drug development is the process of finding and producing therapeutically useful pharmaceuticals, turning them into safe and effective medicine, and producing reliable information regarding the.

This book aims to explain the statistical issues in drug development to non-statisticians, so enabling them to work more easily alongside their statistical colleagues in.

Statistical Issues in Drug Development presents an essential and thought provoking guide to the statistical issues and controversies involved in drug : Stephen Senn.

Statistical Issues in the Design and Analysis of Clinical Trials. which have been proposed for trials with high placebo response rates which can lead to a higher failure rate in drug.

The statistical issues in drug development are explained in this book, enabling non-statistians to work more easily alongside their statistical colleagues in planning, analysing and interpreting clinical trials.

The author aims to make the book of particularly benefit to the physician who might have little access to statistical expertise.5/5(1). Until recently he was Professor of Pharmaceutical and Health Statistics at University College London but since September he has been Professor of Statistics at Glasgow University.

His books, Cross-over Trials in Clinical Research (, 2 nd edition ) and Statistical Issues in Drug Development () are published by Wiley and his. Statistical issues in drug development. [Stephen Senn] -- "Statistical Issues in Drug Development presents an essential and thought provoking guide to the statistical issues and controversies involved in drug development.

ISBN: OCLC Number: Description: pages ; 24 cm. Contents: 1. Introduction --Part I: Four views of statistics in drug development: historical, methodological, technical and professional A brief and superficial history of statistics for drug developers Design and interpretation of clinical trials as seen by a statistician The author’s knowledge of statistics in drug development 4 The reader and his or her knowledge of statistics 4 How to use the book 5 References 6 Part 1 Four Views of Statistics in Drug Development: Historical, Methodological, Technical and Professional 9 2 A Brief and Superficial History of Statistics for Drug Developers 11   Statistical Issues in Drug Development presents an essential and thought provoking guide to the statistical issues and controversies involved in drug development.

Book Description. This book is a compilation of topics addressed by the ASA Biopharmaceutical Section work groups, including the etiology and evolution of the work groups, the work group guidelines and structure, and the statistical issues associated with clinical trials in clinical drug development .Statistical Issues in Drug Development Second edition by Stephen Senn.

Statistical Issues in Drug Development, 2nd edition presents an essential and thought stimulating guide to the statistical issues and controversies involved in drug development. Features: Comprehensive coverage of the design and interpretation of clinical trials.The Swedish Association of Medical Statistics (FMS) and The Danish Society for Biopharmaceutical Statistics (DSBS) organize jointly a one-day meeting in Malmö on the 6th of May am – 5 pm on Statistical Issues in Drug Development Key note speaker: Professor Stephen Senn.